This Spanish-style hotel near Torrey Pines State Natural Reserve – stitched with 3,000 rare trees – is spread over 10 acres of succulent-studded gardens and home to one of the best spas in Southern California. Book a whole day to enjoy a tension-busting CBD-oil massage, relax in the eucalyptus-scented steam room and swim in the saltwater pool (reserve a cabana in advance for the ultimate shady lounging spot). There’s also a meditation garden and private yoga classes on request.

This plant-based micro chain has spread its good vibes across California, including this branch in Little Italy. Mindful eating is a given here – the plates are etched with the question “What are you grateful for?” – and each organic dish has an inspiring name such as Humble, Brave or Blessed. You might even get ecstatic about the maple miso-glazed brussel sprouts. The drinks menu has everything you’d expect from a wellness-focused restaurant, including superfood smoothies and turmeric lattes.

Drawing on Eastern and Western techniques and traditions, practitioners at Place360 in Del Mar take a holistic approach to treating clients. Everything from anti-aging facials and massages to reiki, cupping and acupuncture will be tailored to your wellness needs. If alternative therapies are your thing, don’t miss the guided chakra-balancing meditation on a Biomat: an infrared-heated mat, lined with healing amethyst crystals.

Fans of Marilyn Monroe may recognize this grand beachfront resort as the Seminole Ritz – the ‘Miami’ hotel from the classic romantic comedy Some Like it Hot (1959). In reality, it’s a true California dream, with Pacific Ocean views, mermaid-themed water-aerobics classes and ocean-inspired spa treatments (try the algae-infused facial). Swing by the watersports center to hire an SUP board or book a surf lesson.

You could spend a week in Balboa Park and still not see it all. Its sprawling 1,200 acres include art galleries, cultural centers, the Natural History Museum and San Diego Zoo. But those seeking a chance to immerse themselves in nature will have ample opportunity. Take your pick of the many gardens – Palm Canyon hosts 50 different species, while the Desert Garden is packed with drought-resistant plants – or follow one of the challenging, tree-lined hiking trails.

California isn’t just about the beach. This 43-acre estate, just north of the city, features sprawling gardens and a collection of luxurious casitas with vaulted ceilings and private patios. Fresh orange juice, direct from the citrus grove, is delivered to your room each morning. From then on, it’s a case of choosing your own adventure. Get tennis coaching from a former pro, practice warrior posture in the floating yoga pavilion, get pampered at the spa, or lounge by the outdoor pool.

Head to the quirky, LGBT-friendly neighborhood of Hillcrest for a sweaty workout at Salt Pilates. Classes engage both body and mind and focus on firing up your core. Some sessions are heated to between 85F (29C) and 95F (35C), which is said to help your body flush out toxins, improve muscle recovery and promote relaxation. Choose between HIIT-style sets, sequences backtracked by upbeat tunes, and slow-paced, stretchy flows.

Want a lazy beach day with a casual, hippy vibe? Head to the boho neighborhood of Ocean Beach, where you can browse artists’ stalls and second-hand record shops and sip organic smoothies on the sand before heading into the waves for a surf lesson. For a life-affirming finale, head south along the Sunset Cliffs Coastal Trail to soak in the epic sunset views.