Deep in the heart of the American West, the Resort at Paws Up is for the traveler who wants a wilderness escape to include all the comforts of civilization. The lodgings here come with full kitchens, laundry, and in most cases a fireplace or a wood-burning stove. The design may be rustic, but the comforts are modern.

The Gold Rush town of Nevada City, California has settled into a second life as an outdoor-friendly bohemian enclave in the foothills of the Sierras; no surprise, then, that the town’s 1856-vintage Victorian lodging, the National Exchange Hotel, has found new purpose as a stylish and modern (if retro-styled) boutique hotel.

The Zion in question is southwestern Utah’s spectacular Zion National Park. Zion’s Tiny Oasis lies just outside of the park proper, and while the oasis itself is tiny, so is each of its four units: they’re freestanding “tiny houses,” ranging in size from the 289-square-foot Guardian Angel to the 488-square foot King Solomon. The original homesteaders never had comforts like these.

Inn of the Anasazi — named for the ancient civilization that built the region’s distinctive cliff dwellings — offers an unusually authentic and culturally sensitive New Mexican experience. The interiors are antique in style, and the work of New Mexican and Native American artists and craftspeople is featured prominently throughout.

Here, in remote southwestern Colorado, halfway between the ski town of Telluride and the Anasazi ruins of Mesa Verde, is an authentic ghost town, an abandoned century-old gold prospectors’ camp, renovated shack by shack and rehabilitated into Dunton Hot Springs, a truly unique luxury hotel.

The California Gold Rush town of Grass Valley, in the Sierra foothills, is something of a waystation for travelers between San Francisco and the Sierra mountains. But the Holbrooke Hotel makes a compelling case as a destination unto itself. It’s the region’s longest-operating hotel, but it’s not stuck in the past.

Pioneertown was born when Hollywood Western stars got sick of traveling long distances to find Old West atmosphere, and established their own Westworld in the desert near Joshua Tree. Thanks to festivals like Coachella, the town, today, is for real. And in the Pioneertown Motel, it’s got its very own boutique hotel.

By the standards of Old Town Fort Collins, a classic Old West town, the 1923-vintage Armstrong Hotel is a relative newcomer. In advance of its 100th birthday it’s been thoroughly updated to modern boutique-hotel standards, with swanky, stylish rooms and a pair of highly regarded dining and drinking venues.

The mountainous western edge of Montana doesn’t quite call for edgy urban-inspired modern design. But there’s more than one way to make an extraordinary hotel. Alpine Falls Ranch takes a classic mountain-lodge aesthetic and simply executes it with commitment, with verve, and with a rare tastefulness.

El Cosmico leaves the traditional hotel world behind, trading in rooms and suites for trailers, yurts, tents and tepees, a sort of post-hippie hospitality commune on the outskirts of Marfa, itself something of an oasis of creativity in the vast expanse of West Texas. And for a nominal fee, you can even pitch a tent on site.